Activated alumina spheres have many capillary channels and large surface area, which can be used as adsorbent, desiccant and catalyst. At the same time, according to the polarity of the adsorbed material, it has strong affinity for water, oxide, acetic acid, alkali, etc. it is a kind of activated alumina defluorination resin, similar to anion exchange resin, but has high selectivity for fluoride ion. Activated alumina adsorption defluorination effect is good, the capacity is stable, every cubic meter of activated alumina fluoride absorption 6400 grams. This product has the advantages of high strength, low wear, no swelling, no pulverization and no cracking. It can be widely used in deep drying of petroleum cracking gas, ethylene propylene gas and hydrogen production, drying of air separation unit, instrument air dryer, fluoride treatment of dioxygen water, and removal of sulfur gas, hydrogen, sulfur dioxide, hydrogen fluoride, hydrocarbon and other pollutants in waste gas, especially suitable for defluorination treatment of fluorine-containing water. Micro water deep desiccant is also an adsorbent for adsorbing polar molecules.